The Toon Headquarters, commonly known as the "Toon HQ'", is a building located on every playground and every street, excluding Chip 'n Dale's Acorn Acres and Goofy Speedway. Every headquarters is equipped with a periscope or telescope and an alarm system, as they are always on the lookout for the Cogs. Inside the building, four HQ Officers offer ToonTasks for rewards.
The exteriors of the Toon Headquarters are based around the theme of the playground areas. In Toontown Central, the building is a fire station with a roof in the shape of a firefighter hat. In Donald's Dock, the headquarters are shaped like ocean liners with sailor hats for the roof. In Daisy Gardens, the buildings resemble giant watering cans with pink bowl hats. In Minnie's Melodyland, the building is a gigantic jukebox wearing headphones. In The Brrrgh, the building that houses the headquarters is an igloo topped with a winter hat. In Donald's Dreamland, the building is a star observatory with a telescope that is focused at the sky, and has a roof like a night cap.
The interiors of the Toon Headquarters from each playground are similar, but the HQ Officers always differ. The rooms are an octagonal shape, with a laboratory, test chamber, two doorways, and five blackboards. One blackboard has the Toon Platoon showing the top ten Toons with the most points for recovered Cog Buildings. The other four chalkboards display machine concepts, including things such as a banana-peeling machine and "Super Squirting Flowers". In the center of the room is a square booth surrounding the periscope fitted with sirens. The HQ Officers stand at these booths.
- The Toon Headquarters in Toontown Central is the only one to have two telescopes that are animated.
- An update on April 1, 2018 implemented a second telescope to the Toon Headquarters.
- There are plans for Field Offices to take over the Toon Headquarters instead of ordinary Toon Buildings.